She subsequently published the novels Que se quede el infinito sin estrellas (2001) and Eses fatales (2005), which Manzano described as 'a genocentric discourse in which esses and feces converge as the characteristics of the most profound loneliness' and that explore topics such as literary creations, solitude and lesbian love. Her first novel, Y no abras la ventana todavía, won the first prize in the 'Bienal de Novela Ecuatoriana' contest in 1993. Her second short fiction book, Trata de viejas (2015), contains 10 stories filled with black humor that dig into nostalgia, loneliness and other problems of old age.

Her book Flujo escarlata won the 1999 Joaquín Gallegos Lara National Fiction Prize in the category Best Short-Story Collection. Manzano also became a proficient short fiction writer, having obtained the 1989 Ecuadorian Feminist Short-Story Contest. Other poetry books published by Manzano include Patente de corza (1997), Último regreso a Edén (2007) and Espalda mordida por el humo (2014).

She then published Casi siempre las tardes (1974), La gota en el cráneo (1976), La semana que no tiene jueves (1978), El ave que todo lo atropella (1980), Caja musical con bailarina incluida (1984), Carcoma con forma de paloma (1986) and Full de reinas (1991), which achieved commercial success. Her first poetry book was El nudo y el trino, printed in 1972. She started her literary career when some of her poems appeared in the anthology Generación Huracanada (1970), which was also the name of a literary group of which Manzano was part. Sonia Manzano Vela (born Guayaquil, 27 February 1947) is an Ecuadorian writer and poet. Joaquín Gallegos Lara National Fiction Prize (1999)

Eses fatales by Sonia Manzano Vela